2017-present (UT Southwestern)

Phosphorylation of histone H3.3 at serine 31 promotes p300 activity and enhancer acetylation. Martire, S., Gogate, A.A., Whitmill, A., Tafessu, A., Nguyen, J., Teng, Y.-C., Tastemel, M., Banaszynski, L.A. (2019). Nature Genetics. 51,941-946.

Histone variant H3.3-mediated chromatin remodeling is essential for paternal genome activation in mouse preimplantation embryos. Kong, Q., Banaszynski, L.A., Geng, F., Zhang, X., Zhang, J., Zhang, H., O'Neill, C.L., Yan, P., Liu, Z., Shido, K., Palermo, G.D., Allis, C.D., Rafii, S., Rosenwaks, Z., Wen, D. (2018). J. Biol. Chem. 293, 3829-3838.

Transcription pausing regulates mouse embryonic stem cell differentiation. Tastemel, M., Gogate, A.A., Malladi, V.S., Nguyen, K., Mitchell, C., Banaszynski, L.A., Bai, X. (2017). Stem Cell Res. 25, 250-255.

Checks and balances: Rpd3 issues executive orders in developmental enhancer regulation. Martire, S., Banaszynski, L. (2017). Dev. Cell 40, 325-326. (Preview)

2010-2015 (Postdoc with David Allis at Rockefeller University)

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells. Elsässer, S.J., Noh, K.-M., Diaz, N., Allis, C.D., Banaszynski, L.A. (2015). Nature 522, 240-244. *Correction here.

Targeting the endogenous h3f3b (H3.3B) locus for a reporter of gene expression in mice. Wen, D., Noh, K.-M., Golberg, A.D., Allis, C.D., Rosenwaks, Z., Rafii, S., Banaszynski, L.A. (2014). Genesis 52, 959-966.

H3.3 replacement facilitates epigenetic reprogramming of donor nuclei in somatic cell nuclear transfer (SCNT) embryos. Wen, D., Banaszynski, L.A., Rosenwaks, Z., Allis, C.D., Rafii, S. (2014). Nucleus 5, 369-375.

Histone variant H3.3 is an essential maternal factor for oocyte reprogramming. Wen, D., Banaszynski, L.A., Liu, Y., Xiang, J., Elemento, O., Rosenwaks, Z., Allis, C.D., Rafii, S. (2014). Proc. Natl. Acad. Sci. 111, 7325-7330.

Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells. Banaszynski, L.A., Wen, D., Dewell, S., Whitcomb, S.J., Lin, M., Diaz, N., Elsässer, S.J., Chapgier, A., Goldberg, A.D., Canaani, E., Rafii, S., Zheng, D., Allis, C.D. (2013). Cell 155, 107-120.

Inhibition of PRC2 activity by gain-of-function H3 mutants found in pediatric glioblastomas. Lewis, P.W., Muller, M.M., Koletsky, M.S., Cordero, F., Lin, S., Banaszynski, L.A., Garcia, B.A., Muir, T.W., Becher, O.J., Allis, C.D. (2013). Science 340, 857-861.

Distinct factors control histone variant H3.3 localization at specific genomic regions. Goldberg, A.D., Banaszynski, L.A., Noh, K.-M., Lewis, P.W., …, Allis, C.D. (2010). Cell 140, 678-691.

Histone variants in metazoan development. Banaszynski, L.A., Allis, C.D., and Lewis, P.W. (2010). Dev. Cell 19, 662-674. (Review)

Analysis of histones and chromatin in Xenopus laevis egg and oocyte extracts. Banaszynski, L.A., Allis, C.D., Shechter, D. (2010). Methods 51, 3-10

2005-2009 (Graduate Student with Tom Wandless at Stanford UNIVERSITY)

A general method for conditional regulation of protein stability in living animals. Sellmyer, M.A., Thorne, S.H., Banaszynski, L.A., Contag, C.H., and Wandless, T.J. (2009). CSH Protocols doi: 10.1101/pdb.prot5173.

Regulating protein stability in mammalian cells using small molecules. Hagan, E.L., Banaszynski, L.A., Chen, L.-C., Maynard-Smith, L.A., and Wandless, T.J. (2009). CSH Protocols doi: 10.1101/pdb.prot5172.

Chemical control of protein stability and function in living animals. Banaszynski, L.A., Sellmyer, M.A., Contag, C.H., Wandless, T.J., Thorne, S.H. (2008). Nat. Med. 14, 1123-1127.

Recent progress with FKBP-derived destabilizing domains. Chu, B.W., Banaszynski, L.A., Chen, L.-C., Wandless, T.J. (2008). Bioorg. Med. Chem. Lett. 18, 5941-5944.

Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains. Grimley, J.S., Chen, D.A., Banaszynski, L.A., Wandless, T.J. (2008). Bioorg. Med. Chem. Lett. 18, 759-761.

A directed approach for engineering conditional protein stability using biologically silent small molecules. Maynard-Smith, L.A., Chen, L.-C., Banaszynski, L.A., Ooi, A.G.L., Wandless, T.J. (2007). J. Biol. Chem. 282, 24866-24872.

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Berdeaux, R., Goebel, N., Banaszynski, L., Takemori, H., Wandless, T., Shelton, G.D., Montminy, M. (2007). Nat. Med. 13, 597-603.

A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Banaszynski, L.A., Chen, L.-C., Maynard-Smith, L.A., Ooi, A.G.L., Wandless, T.J. (2006). Cell 126, 995-1004.

Conditional control of protein function. Banaszynski, L.A., Wandless, T.J. (2006). Chem. Biol. 13, 11-21. (Review)

Characterization of the FKBP•rapamycin•FRB ternary complex. Banaszynski, L.A., Liu, C.W., Wandless, T.J. (2005). J. Am. Chem. Soc. 127, 4715-4721

Pre-2005 (Undergraduate at University of Notre Dame)

Using hydrogen bonding to control carbamate C-N rotamer equilibria. Moraczewski, A.L., Banaszynski, L.A., From, A.M., White, C.E., Smith, B.D. (1998). J. Org. Chem. 63, 7258-7262.